Product Name: 3,4,5-Trimethoxybenzaldehyde
Chemical Formula: C10H12O4
Synonyms: Trimethoxybenzaldehyde, TMB, Benzenecarboxaldehyde, 3,4,5-trimethoxy-
CAS Number: 86-81-7
Recommended Use: Laboratory chemicals, pharmaceutical intermediates, research and development
Manufacturer: Varies by supplier, check container label
Contact Information: Refer to manufacturer or responsible party for up-to-date emergency contacts
Emergency Phone: Chemtrec or local emergency numbers listed on shipment documentation
GHS Classification: Not classified as hazardous under GHS standards in many jurisdictions
Hazard Statements: May cause skin and eye irritation, inhalation of dust may cause respiratory tract irritation, ingestion may cause gastrointestinal discomfort
Precautionary Statements: Avoid dust formation, avoid breathing vapors, wash hands thoroughly after handling, use personal protective equipment as required
Signal Word: None specifically assigned
Pictograms: No pictogram required, use caution and good laboratory practice
Routes of Exposure: Eyes, skin, inhalation, ingestion
Target Organs: Eyes, skin, respiratory tract
Chemical Name: 3,4,5-Trimethoxybenzaldehyde
CAS Number: 86-81-7
Concentration: 98% or greater by weight as pure substance
Impurities/Admixtures: Trace levels of related methoxybenzaldehydes, formaldehyde (<0.1%), residual solvents from synthesis, usually ethanol, methanol, or water
General Measures: Remove person from exposure, ensure access to clean air, seek medical attention if symptoms develop
Eye Contact: Rinse cautiously with water for 15 minutes, remove contact lenses if present, consult a physician if irritation persists
Skin Contact: Wash area thoroughly with soap and water, remove contaminated clothing, seek medical advice if irritation develops
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by medical personnel, seek medical help
Inhalation: Move to fresh air, provide oxygen if breathing is difficult, administer artificial respiration if not breathing, call for emergency assistance
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, or foam
Unsuitable Media: Do not use direct stream of water as product may float on surface and spread fire
Hazards from Combustion: Produces irritating or toxic fumes of carbon monoxide, carbon dioxide, potentially formaldehyde upon burning
Protective Equipment for Firefighters: Wear positive-pressure self-contained breathing apparatus and full protective gear
Fire Hazards: May form combustible dust concentrations, keep containers cool with water spray
Explosion Data: Not sensitive to mechanical impact or static discharge in usual conditions but dust can form explosive mixtures with air
Spill Response: Ventilate area, evacuate unnecessary personnel, eliminate sources of ignition
Personal Precautions: Use protective gloves, safety goggles, dust respirator if needed
Environmental Precautions: Prevent entry into sewers, drains, water bodies, minimize runoff
Containment Methods: Cover spill with inert absorbent (sand, vermiculite), scoop up and collect in a properly labeled container for disposal
Cleanup Methods: Moisten powder to avoid dust formation, clean affected area thoroughly after material pick-up
Disposal: Dispose as hazardous chemical waste per local regulations
Handling: Work in well-ventilated area, avoid generating dust or aerosols, use with appropriate personal protection, wash after handling
Storage Conditions: Store in a tightly sealed container in a cool, dry, well-ventilated place, keep away from incompatible substances such as strong oxidizers or acids
Special Precautions: Protect from light, moisture, and sources of ignition, keep away from food and drink
Incompatibilities: Strong acids, strong bases, strong oxidizing agents
Storage Class: Chemical storage, general organic solids
Engineering Controls: Use in chemical fume hood, provide eyewash stations and safety showers
Personal Protective Equipment: Safety glasses with side shields, chemical-resistant gloves (nitrile or neoprene), lab coat, dust mask or respirator for dusty conditions
Hygiene Measures: Wash hands and exposed skin after use, remove and wash contaminated clothing before reuse, avoid eating, drinking, or smoking in work area
Exposure Limits: No specific Occupational Exposure Limits established, follow general workplace standards for organic solids
Monitoring: Regular air monitoring in high-use or production settings
Appearance: Off-white to pale yellow crystalline powder
Odor: Faint, characteristic aromatic, slightly sweet
Molecular Weight: 196.2 g/mol
Melting Point: 73–75 °C
Boiling Point: 170–175 °C at 1 mmHg
Flash Point: >110 °C (closed cup, approximate)
Solubility: Slightly soluble in water, soluble in ethanol, methanol, chloroform, ether
Density: 1.2–1.3 g/cm³
Vapor Pressure: Negligible at room temperature
Partition Coefficient: log Kow ~ 2.0
pH: Not applicable (neutral solid)
Stability: Stable under recommended storage conditions, may discolour slowly if exposed to air and light
Reactive Properties: Reactive with strong oxidizers, acids, and bases, can undergo aldol condensation and other organic reactions
Conditions to Avoid: Heat, open flames, strong sunlight, high humidity
Incompatible Materials: Strong oxidizing agents, strong acids and bases
Hazardous Decomposition: Emits toxic fumes of carbon monoxide, carbon dioxide, and traces of formaldehyde or methoxy compounds under fire conditions
Polymerization: Not expected to occur under normal storage or handling
Acute Toxicity: LD50 (oral, rat) >2000 mg/kg, low acute toxicity anticipated
Skin Corrosion/Irritation: May cause mild skin irritation with prolonged or repeated exposure
Eye Damage/Irritation: Dust or solid may cause moderate eye irritation
Respiratory Sensitization: Not expected under normal use, dust may irritate upper respiratory tract
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, OSHA
Mutagenicity: No evidence reported in standard assays
Reproductive Effects: No known reproductive hazards reported
Possible Health Effects: Prolonged exposure to high concentrations may affect liver, kidneys or central nervous system based on structural analogs
Ecotoxicity: No data on aquatic toxicity for this specific compound, analogs show low aquatic toxicity
Mobility: Low solubility in water, expected to adsorb to soil and sediment
Persistence and Degradability: Expected to be slowly biodegradable in the environment, may persist under low-oxygen or cold conditions
Bioaccumulative Potential: Moderate based on octanol-water partition coefficient
Other Adverse Effects: Do not allow product to reach waterways, sewers, or soil; handle to minimize ecological impact
Disposal Methods: Dispose of in accordance with local, regional, national, and international regulations as hazardous chemical waste
Storage for Disposal: Keep waste in sealed, labeled containers compatible with organic compounds
Recycling/Reclamation: Contact chemical waste facility to determine recycling options
Precautions: Avoid discharge into environment, separate from incompatible wastes, do not mix with household garbage
Disposal Agency Contact: Contact licensed hazardous waste disposal contractor for removal and destruction
UN Number: Not assigned for this material under standard UN transport regulations
Proper Shipping Name: Not regulated as a hazardous material for ground, air, or sea transport in many countries
Hazard Class: Not classified as dangerous goods
Packing Group: Not applicable
Marine Pollutant: No
Transport Precautions: Use sealed packaging, prevent release to environment, label in compliance with local requirements
Special Transport Notes: Check with carrier for restrictions, report any spills immediately if they occur in transport
TSCA (US): Listed
REACH (EU): Registered or exempt based on use and volume
Canada DSL/NDSL: Listed
Australia AICS: Listed
WHMIS Classification: Not controlled under WHMIS
SARA Title III: Not reportable under Sections 302, 304, or 313
California Prop 65: Not listed
Other Regulations: Handle coordination with institutional or government safety office, adherence to workplace chemical safety laws is required
Labeling Requirements: Follow local regulation for hazard labeling and documentation on containers and storage locations
